PRESSURE INCREASES TO FIND DENNY A NEW HEART, CRISTINA TAKES OVER IN THE ER, DEREK HAS THE LIFE OF A FRIEND IN HIS HANDS, RICHARD CONFRONTS THE INTERNS OVER A PATIENT�S CONDITION, AND MEREDITH AND DEREK MEET ABOUT DOC, ON A TWO-HOUR STORY ARC OF ABC�S �GREY�S ANATOMY�

Chris O�Donnell Guest Stars

In the first hour of part two-hour story arc of ABC�s �Grey�s Anatomy� -- �Deterioration of the Fight or Flight Response� -- Izzie and George attend to Denny as the pressure increases to find him a new heart, Cristina suddenly finds herself in charge of an ER, and Derek grapples with the realization that the life of a friend is in his hands. In the second hour, �Losing My Religion,� Richard goes into interrogation mode about a patient�s condition, Callie confronts George about his feelings for her, and Meredith and Derek meet about Doc. �Grey�s Anatomy� airs WEDNESDAY, SEPTEMBER 20 (9:00-11:00 p.m., ET) on the ABC Television Network. (Rebroadcast. OAD 5/15/06)

�Grey�s Anatomy� stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Isaiah Washington as Preston Burke, Katherine Heigl as Isobel �Izzie� Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O�Malley, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber and Kate Walsh as Addison Shepherd.

Guest cast: Chris O�Donnell as Dr. Finn Dandridge, Sara Ramirez as Callie, Jeffrey Dean Morgan as Denny, Loretta Devine as Adele Webber, Hallee Hirsh as Claire, Tessa Thompson as Camille, Tiffany Hines as Natalie and Brooke Smith as Dr. Erica Hahn.

�Deterioration of the Fight or Flight Response� was written by Tony Phelan and Joan Rater and directed by Rob Corn.

�Losing My Religion� was written by Shonda Rhimes and directed by Mark Tinker.

�Grey�s Anatomy� is broadcast in 720 Progressive (720P), ABC�s selected HDTV format, with 5.1-channel surround sound and Spanish subtitles via secondary closed captioning.

This program carries a TV-14,D,S parental guideline.