WHILE PROFILING A KILLER WITH A PERSONAL VENDETTA AGAINST AN EMERGENCY ROOM DOCTOR, THE BAU TEAM DISCOVERS THAT HOTCH IS MISSING, ON THE FIFTH SEASON PREMIERE OF "CRIMINAL MINDS," WEDNESDAY, SEPT. 23

"Nameless, Faceless" - Hotch's unexplained absence quickly becomes apparent when the team is called back together to profile a killer who is targeting an emergency room doctor, on the fifth season premiere of CRIMINAL MINDS, Wednesday, Sept. 23 (9:00-10:00 PM, ET/PT) on the CBS Television Network.

SERIES REGULARS:

David Rossi................................ Joe Mantegna
Aaron Hotchner....................... Thomas Gibson
Emily Prentiss........................... Paget Brewster
Derek Morgan.......................... Shemar Moore
Dr. Spencer Reid........... Matthew Gray Gubler
Jennifer Jareau................................. A.J. Cook
Penelope Garcia.................. Kirsten Vangsness

GUEST CAST:

Detective Walker.......................... John Eddins
Dr. Barton........................ Christopher Cousins
Jeffrey Barton............................... Paul Butcher
Principal Sheila Findlay.................. Kelly Lloyd
Patrick Meyers.......................... Michael Adler
Dr. Zwerling................................. Laura Niemi
The Reaper/George Foyet...................... C. Thomas Howell
SWAT Commander.............. Gary P. Stein, Jr.
Haley Hotchner.................... Meredith Monroe
Jack Hotchner............................. Cade Owens
US Marshall.............................. D.B. Sweeney
Grieving Mother........................... Norma Hans

WRITTEN BY: Chris Mundy, one of the series' executive producers

DIRECTED BY: Charles S. Carroll

RATING: To Be Announced